Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development.

@article{GalveRoperh2006EndocannabinoidsAN,
  title={Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development.},
  author={Ismael Galve-Roperh and Tania Aguado and Daniel Rueda and Guillermo Velasco and M {\'A}ngeles Guzm{\'a}n},
  journal={Current pharmaceutical design},
  year={2006},
  volume={12 18},
  pages={
          2319-25
        }
}
The endocannabinoids (eCBs) anandamide and 2-arachidonoylglycerol are important retrograde messengers that inhibit neurotransmitter release via presynaptic CB1 receptors. In addition, cannabinoids are known to modulate the cell death/survival decision of different neural cell types, leading to different outcomes that depend on the nature of the target cell and its proliferative/differentiation status. Thus, cannabinoids protect primary neurons, astrocytes and oligodendrocytes from apoptosis… CONTINUE READING