Endocannabinoid tone versus constitutive activity of cannabinoid receptors.

Abstract

This review evaluates the cellular mechanisms of constitutive activity of the cannabinoid (CB) receptors, its reversal by inverse agonists, and discusses the pitfalls and problems in the interpretation of the research data. The notion is presented that endogenously produced anandamide (AEA) and 2-arachidonoylglycerol (2-AG) serve as autocrine or paracrine… (More)
DOI: 10.1111/j.1476-5381.2011.01364.x

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