Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex.

@article{Trettel2004EndocannabinoidSS,
  title={Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex.},
  author={Joseph Trettel and Dale A Fortin and Eric S Levine},
  journal={The Journal of physiology},
  year={2004},
  volume={556 Pt 1},
  pages={95-107}
}
Retrograde synaptic signalling has long been recognized as a fundamental feature of neural systems. However, the cellular specificity and functional consequences of fast retrograde communication are not well understood. We have focused our efforts on understanding the role that endocannabinoids play in regulating synaptic inhibition in sensory neocortex. Recent studies have implicated endocannabinoids as the retrograde signalling molecules that underlie depolarization-induced suppression of… CONTINUE READING