Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis.

Abstract

Activation of the hypothalamic-pituitary-adrenal (HPA) axis is critical for the adaptation and survival of animals upon exposure to stressful stimuli, and data suggest that endocannabinoid (eCB) signaling modulates neuroendocrine function. We have explored the role of eCB signaling in the modulation of stress-induced HPA axis activation. Administration of… (More)

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Cite this paper

@article{Patel2004EndocannabinoidSN, title={Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis.}, author={Sachin Patel and Craig T. Roelke and David J. Rademacher and William E. Cullinan and Cecilia J. Hillard}, journal={Endocrinology}, year={2004}, volume={145 12}, pages={5431-8} }