Endocannabinoid signaling mediates psychomotor activation by adenosine A2A antagonists.

Abstract

Adenosine A(2A) receptor antagonists are psychomotor stimulants that also hold therapeutic promise for movement disorders. However, the molecular mechanisms underlying their stimulant properties are not well understood. Here, we show that the robust increase in locomotor activity induced by an A(2A) antagonist in vivo is greatly attenuated by antagonizing… (More)
DOI: 10.1523/JNEUROSCI.5844-09.2010

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