Endocannabinoid signaling in the brain.

  title={Endocannabinoid signaling in the brain.},
  author={Rachel I. Wilson and Roger A Nicoll},
  volume={296 5568},
The primary psychoactive ingredient in cannabis, Delta9-tetrahydrocannabinol (Delta9-THC), affects the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels in many brain regions, and several endogenous brain lipids have been identified as CB1 ligands. In contrast to classical neurotransmitters, endogenous cannabinoids can function as retrograde synaptic messengers: They are released from postsynaptic neurons and travel backward across synapses, activating CB1 on… CONTINUE READING
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