Endocannabinoid signaling depends on the spatial pattern of synapse activation

  title={Endocannabinoid signaling depends on the spatial pattern of synapse activation},
  author={Pa{\"i}kan Marcaggi and David Attwell},
  journal={Nature Neuroscience},
The brain's endocannabinoid retrograde messenger system decreases presynaptic transmitter release, but its physiological function is uncertain. We show that endocannabinoid signaling is absent when spatially dispersed synapses are activated on rodent cerebellar Purkinje cells but that it reduces presynaptic glutamate release when nearby synapses are active. This switching of signaling according to the spatial pattern of activity is controlled by postsynaptic type I metabotropic glutamate… CONTINUE READING
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