Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex.

@article{Sticht2016EndocannabinoidRO,
  title={Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex.},
  author={Martin A Sticht and Cheryl L. Limebeer and Benjamin R Rafla and Rehab A. Abdullah and Justin L Poklis and Winnie S Ho and Micah J. Niphakis and Benjamin F Cravatt and Keith A Sharkey and Aron H. Lichtman and Linda A Parker},
  journal={Neuropharmacology},
  year={2016},
  volume={102},
  pages={92-102}
}
Cannabinoid (CB) agonists suppress nausea in humans and animal models; yet, their underlying neural substrates remain largely unknown. Evidence suggests that the visceral insular cortex (VIC) plays a critical role in nausea. Given the expression of CB1 receptors and the presence of endocannabinoids in this brain region, we hypothesized that the VIC endocannabinoid system regulates nausea. In the present study, we assessed whether inhibiting the primary endocannabinoid hydrolytic enzymes in the… CONTINUE READING
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