Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum.

@article{Narushima2006EndocannabinoidmediatedSS,
  title={Endocannabinoid-mediated short-term suppression of excitatory synaptic transmission to medium spiny neurons in the striatum.},
  author={Madoka Narushima and Kouichi Hashimoto and Masanobu Kano},
  journal={Neuroscience research},
  year={2006},
  volume={54 3},
  pages={159-64}
}
Medium spiny neurons in the dorsal striatum receive glutamatergic excitatory synaptic inputs from the cerebral cortex. These synapses undergo long-term depression that requires release of endocannabinoids from medium spiny neurons and activation of cannabinoid CB1 receptors. However, it remains unclear how cortico-striatal synapses exhibit endocannabinoid-mediated short-term suppression, which has been found in various brain regions including the hippocampus and cerebellum. Endocannabinoids are… CONTINUE READING
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