Endocannabinoid-Mediated Metaplasticity in the Hippocampus

@article{Chevaleyre2004EndocannabinoidMediatedMI,
  title={Endocannabinoid-Mediated Metaplasticity in the Hippocampus},
  author={Vivien Chevaleyre and Pablo E. Castillo},
  journal={Neuron},
  year={2004},
  volume={43},
  pages={871-881}
}
Repetitive activation of glutamatergic fibers that normally induces long-term potentiation (LTP) at excitatory synapses in the hippocampus also triggers long-term depression at inhibitory synapses (I-LTD) via retrograde endocannabinoid signaling. Little is known, however, about the physiological significance of I-LTD. Here, we show that synaptic-driven release of endocannabinoids is a highly localized and efficient process that strongly depresses cannabinoid-sensitive inhibitory inputs within… Expand
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