Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition.

@article{Nakajima2006EndocannabinoidAI,
  title={Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition.},
  author={Yumiko Nakajima and Yasushi Furuichi and Kamal Krishna Biswas and Teruto Hashiguchi and Ko-Ichi Kawahara and Kazuyo Yamaji and Tomonori Uchimura and Yuichi Izumi and Ikuro Maruyama},
  journal={FEBS letters},
  year={2006},
  volume={580 2},
  pages={613-9}
}
Anandamide (AEA) exhibits anti-inflammatory effects. However, its role in the periodontal field remains unknown. Here, we found that gingival crevicular fluid contained a detectable level of AEA. The cannabinoid receptors CB1 and CB2 were expressed by human gingival fibroblasts (HGFs), and markedly upregulated under pathological conditions. AEA significantly reduced the production of pro-inflammatory mediators (IL-6, IL-8 and MCP-1) induced by Porphyromonas gingivalis LPS in HGFs, and this… CONTINUE READING