Endobronchial ultrasound‐guided transbronchial needle aspiration diagnosis of mediastinal lymph node metastasis of mucinous adenocarcinoma: Arborizing stromal meshwork fragments as a diagnostic clue

  title={Endobronchial ultrasound‐guided transbronchial needle aspiration diagnosis of mediastinal lymph node metastasis of mucinous adenocarcinoma: Arborizing stromal meshwork fragments as a diagnostic clue},
  author={Arbaz Samad and Justin C Peltola and Mohi O Mitiek and Jose Jessurun and J. Carlos Manivel and Stefan E. Pambuccian},
  journal={Diagnostic Cytopathology},
Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration (EBUS‐TBNA) is a reliable and accurate method for the diagnosis of mediastinal metastases in patients with pulmonary and extrathoracic neoplasms. We report the cytopathologic findings of a case of metastatic signet‐ring cell carcinoma with abundant extracellular mucin production in the mediastinal lymph nodes of a 41‐year‐old woman, who presented with nausea, abdominal pain, and weight loss. Imaging studies showed a renal mass… 
Cytologic features of pancreatic adenocarcinoma with “vacuolated cell pattern.” report of a case diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration
The endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) cytologic features of a case of pancreatic adenocarcinoma with “vacuolated cell pattern” occurring in a 60‐year‐old man allowing its differentiation from primary and metastatic signet‐ring cell carcinomas are reported.
Substernal thyroid biopsy using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration.
A role for EBUS-TBNA is proposed in the diagnosis of substernal thyroid lesions, along with a step-by-step protocol for the procedure, and the ability to perform EBUS as an outpatient procedure with same-day discharges offers distinct morbidity and financial advantages over surgery.
Diagnostic utility of arborizing stromal meshwork fragments in mucinous tumors
The aim was to retrospectively review cytology cases with mucinous material to determine the utility of ASMFs in diagnosing mucinous tumors.


Fine‐needle aspiration diagnosis of metastatic intestinal‐type sinonasal adenocarcinoma
The cytopathologic findings of a case of metastatic sinonasal intestinal type adenocarcinoma (ITAC) in a 58‐year‐old man who presented with enlarged cervical lymph nodes on a follow‐up imaging study, 5 months after resection of a sin onasal ITAC.
Metastatic urothelial carcinoma with signet ring features: Cytomorphologic findings in abdominal paracentesis
The case of a 75‐year‐old male with high‐grade urothelial carcinoma with signet ring features, who was status‐post chemoradiation and radical cystoprostatectomy, is reported, believed to be the first report of metastatic high‐ grade uroclinical carcinoma manifesting asSignet ring cells in peritoneal fluid.
Invasive ductal carcinoma of the breast with signet‐ring cell and mucinous carcinoma components: Diagnostic utility of immunocytochemistry of signet‐ring cells in aspiration cytology materials
It is suggested that immunocytochemical examination of aspiration cytology materials may provide useful information in searching the primary site of breast carcinoma with signet‐ring cells in a 73‐yr‐old Japanese woman.
Diagnostic significance of signet ring cells in fine‐needle aspirates of the breast
The presence of signet ring cells within small loose tissue fragments or as single cells in FNA smears should prompt close clinical follow‐up, regardless of smear cellularity, and rare benign breast lesions may contain signetring ring cells, particularly within large tissue fragments.
Role of transesophageal endosonography-guided fine-needle aspiration in the diagnosis of lung cancer.
EUS-FNA is a safe, reliable, and accurate method to establish the diagnosis of suspected lung cancer when bronchoscopic methods fail, especially in the presence of small nodes.
Colloid cyst of the third ventricle: Cytomorphologic features on stereotactic fine‐needle aspiration
Cytomorphology coupled with the radiologic features is sufficiently unique for the diagnosis of this rare pathologic entity and Stereotactic FNA of the CC of the third ventricle is an accurate and cost‐effective diagnostic modality.
Metastatic signet ring cell carcinoma presenting as a thyroid nodule: Report of a case with fine‐needle aspiration cytology
The purpose of the study is to discuss the cytological features and the differential diagnosis of this unusual thyroid FNA case, which raised the possibility of a metastatic lesion to the thyroid.
Diagnostic difficulties and pitfalls in rapid on-site evaluation of endobronchial ultrasound guided fine needle aspiration
The cytomorphology of five EBUS FNA cases is illustrated to address some of the diagnostic challenges witnessed while examining these specimens during ROSE, including the baseline cellularity of the aspirates, the bronchial contamination, the difficulty identifying neoplasms with bland cytology, the wide spectrum of diseases that can occur in the mediastinum with overlapping cytomorphologic features, and the overall unfamiliarity with these types of specimens.
Ultrasound‐guided fine‐needle aspiration diagnosis of adenocarcinoma of esophagus with signet‐ring cell features arising in Barrett's esophagus: A case report
An incisional biopsy showed Barrett's esophagus with highly atypical glands suspicious for adenocarcinoma, and an ultrasound‐guided endoscopic fine‐needle aspiration revealed a cellular specimen with multiple groups and singly dispersedAtypical glandular cells with a predominance of signet‐ring features.
Signet-ring cell melanoma mimicking adenocarcinoma. A case report.
It is important not to mistake signet-ring cell melanoma for adenocarcinoma in aspiration cytology, and a constellation of clinical features and of histochemical and immunohistochemical findings enables a correct diagnosis to be reached.