Endo-Porter: a novel reagent for safe, effective delivery of substances into cells.

  title={Endo-Porter: a novel reagent for safe, effective delivery of substances into cells.},
  author={James E. Summerton},
  journal={Annals of the New York Academy of Sciences},
Delivering large molecules into the cytosol of animal cells without damaging the cells has been one of the toughest challenges in biology. Endo-Porter is a weak-base amphiphilic peptide that was designed to deliver morpholino antisense oligomers and other non-ionic substances into the cytosol/nuclear compartment of cells by an endocytosis-mediated process that avoids damaging the plasma membrane of the cell. This prevents the loss of vital cell contents and the attendant high cell toxicity… CONTINUE READING


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