End-stage renal disease causes an imbalance between endothelial and smooth muscle progenitor cells.

@article{Westerweel2007EndstageRD,
  title={End-stage renal disease causes an imbalance between endothelial and smooth muscle progenitor cells.},
  author={Peter E. Westerweel and Imo E. Hoefer and Peter J Blankestijn and Petra M de Bree and D. J. A. Groeneveld and Olivia van Oostrom and Branko Braam and Hein A. Koomans and Marianne C Verhaar},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 4},
  pages={F1132-40}
}
Patients with end-stage renal disease (ESRD) on hemodialysis have an increased risk of cardiovascular disease (CVD). Circulating endothelial progenitor cells (EPC) contribute to vascular regeneration and repair, thereby protecting against CVD. However, circulating smooth muscle progenitor cells (SPC) may contribute to adverse vascular remodeling. We hypothesized that an imbalance occurs between EPC and SPC in ESRD patients and sampled progenitor cells from 45 ESRD patients receiving regular… CONTINUE READING
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