End-stage renal disease and recruitment to randomized trials: why is it so difficult? Results from a survey among Norwegian nephrologists.

@article{Lgreid2011EndstageRD,
  title={End-stage renal disease and recruitment to randomized trials: why is it so difficult? Results from a survey among Norwegian nephrologists.},
  author={Inger Karin L{\ae}greid and Knut Ivar Aasar\od and Marit Slaaen Jordh\oy},
  journal={Scandinavian journal of urology and nephrology},
  year={2011},
  volume={45 4},
  pages={285-9}
}
OBJECTIVE Recruitment is one of the most serious challenges in randomized clinical trials (RCTs), especially in the old and frail population. A Norwegian multicentre RCT targeting end-stage renal disease (ESRD) patients older than 70 years was initiated to compare the impact on quality of life of early or late start of dialysis. Owing to poor inclusion the RCT was closed. The aim of the present study was to explore possible reasons for the recruitment failure. MATERIAL AND METHODS A… CONTINUE READING