End points for biomonitoring: assay sensitivity/selectivity.

  title={End points for biomonitoring: assay sensitivity/selectivity.},
  author={C. S. Aaron and David M. Zimmer and Philip R. Harbach and R L Yu},
  journal={Environmental Health Perspectives},
  pages={521 - 525}
Estimation of population exposure and biological impact of potential hazards are central reasons for performing biomonitoring. The sensitivity of the biomonitoring methods and the linkage of the measured phenomenon to human disease are also important, but often overlooked, considerations. We are conducting experiments to evaluate the sensitivity of hprt mutation measurement in the nonhuman primate, the cynomolgus monkey. Our findings demonstrate in the monkey that hypoxanthine guanine… 

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