End-joining, translocations and cancer

  title={End-joining, translocations and cancer},
  author={Samuel F Bunting and Andr{\'e} Nussenzweig},
  journal={Nature Reviews Cancer},
Fusion genes that are caused by chromosome translocations have been recognized for several decades as drivers of deregulated cell growth in certain types of cancer. In recent years, oncogenic fusion genes have been found in many haematological and solid tumours, demonstrating that translocations are a common cause of malignancy. Sequencing approaches have now confirmed that numerous, non-clonal translocations are a typical feature of cancer cells. These chromosome rearrangements are often… CONTINUE READING
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