Encountering and advancing through antiangiogenesis therapy for gliomas.

  title={Encountering and advancing through antiangiogenesis therapy for gliomas.},
  author={Vanesa Martin and Dan Liu and Candelaria G{\'o}mez-Manzano},
  journal={Current pharmaceutical design},
  volume={15 4},
Malignant gliomas, the most common subtype of primary brain tumor, are aggressive, highly invasive, and neurologically destructive. First-line treatment of gliomas consists of surgery and radiotherapy, followed by chemotherapy with temozolomide. However, even with this strong regimen, the prognosis of patients with the most malignant variant, glioblastoma multiforme is poor. Because of the lack of effective treatments and the high vascularity that characterizes these tumors, antiangiogenic… CONTINUE READING


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