Encoding and retrieval of episodic memories: role of cholinergic and GABAergic modulation in the hippocampus.

  title={Encoding and retrieval of episodic memories: role of cholinergic and GABAergic modulation in the hippocampus.},
  author={M E Hasselmo and Bradley P. Wyble and Gene V. Wallenstein},
  volume={6 6},
This research focuses on linking episodic memory function to the cellular physiology of hippocampal neurons, with a particular emphasis on modulatory effects at cholinergic and gamma-aminobutyric acid B receptors. Drugs which block acetylcholine receptors (e.g., scopolamine) have been shown to impair encoding of new information in humans, nonhuman primates, and rodents. Extensive data have been gathered about the cellular effects of acetylcholine in the hippocampus. In this research, models of… CONTINUE READING
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