Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses.


In response to stress, cells induce ribonucleoprotein aggregates, termed stress granules (SGs). SGs are transient loci containing translation-stalled mRNA, which is eventually degraded or recycled for translation. Infection of some viruses, including influenza A virus with a deletion of nonstructural protein 1 (IAVΔNS1), induces SG-like protein aggregates… (More)
DOI: 10.1128/JVI.03248-12


12 Figures and Tables