Encephalitogenic and neuritogenic T cell responses to the myelin-associated glycoprotein (MAG) in the Lewis rat

@article{Weerth1999EncephalitogenicAN,
  title={Encephalitogenic and neuritogenic T cell responses to the myelin-associated glycoprotein (MAG) in the Lewis rat},
  author={Susanna Weerth and Thomas Berger and Hans Lassmann and Christopher Linington},
  journal={Journal of Neuroimmunology},
  year={1999},
  volume={95},
  pages={157-164}
}
Autoimmune responses to the myelin-associated glycoprotein (MAG) are implicated in the immunopathogenesis of both multiple sclerosis (MS) and certain peripheral neuropathies. In this study we demonstrate that T cell responses to defined epitopes of MAG mediate a pathological inflammatory response in the nervous system of the Lewis rat. Peptide-specific T cells were generated against four different MAG epitopes, three of which are common to both L- and S-isoforms of MAG (amino acid (a.a… CONTINUE READING

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