Encephalitis and encephalopathy associated with an influenza epidemic in Japan.

@article{Morishima2002EncephalitisAE,
  title={Encephalitis and encephalopathy associated with an influenza epidemic in Japan.},
  author={Tsuneo Morishima and Takehiro Togashi and Shyumpei Yokota and Yoshinobu Okuno and Chiaki Miyazaki and Masato Tashiro and Nobuhiko Okabe},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2002},
  volume={35 5},
  pages={
          512-7
        }
}
  • T. Morishima, T. Togashi, +4 authors N. Okabe
  • Published 1 September 2002
  • Medicine, Psychology
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
During the winter of 1998-1999, there was an outbreak of encephalitis/encephalopathy in Japan that appeared to be associated with influenza. We conducted a national survey of the prevalence and clinical features of disease and the associated outcomes and prognostic factors related to this outbreak. A total of 202 cases were analyzed, of which 148 were diagnosed as influenza-associated encephalitis/encephalopathy on the basis of virologic analysis. Of the 148 cases studied, 130 (87.8%) were type… 
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A nationwide study in Japan identified patients who had factors associated with a poor prognosis, and these findings might be clinically useful for the management of this illness.
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  • 2010
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A new construct for considering the severe forms of IAE is presented that brings together thinking about pathophysiology with one of three patterns of presentation or syndromes: Encephalopathy caused by metabolic derangement and associated with various inherited metabolic disorders inducing the classic Reye syndrome, or encephalopathy associated with inflammation, hypercytokinemia, and vasogenic cerebral edema.
Acute Encephalopathy Associated with Influenza A Virus Infection
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Influenza A virus–associated acute encephalopathy is frequently associated with metabolic disorders, whereas postinfluenzal encephalopathic appears to have different possible etiologies.
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