Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.

@article{Hillaireau2007EncapsulationOM,
  title={Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.},
  author={Herv{\'e} Hillaireau and Trung Le Doan and H{\'e}l{\'e}ne Chacun and Joel Janin and Patrick Couvreur},
  journal={International journal of pharmaceutics},
  year={2007},
  volume={331 2},
  pages={148-52}
}
In a previous study, we have shown that cidofovir (CDV) and azidothymidine-triphosphate (AZT-TP) were poorly encapsulated in poly(iso-butylcyanoacrylate) (PIBCA) aqueous-core nanocapsules. This was attributed to the rapid leakage of these small and hydrophilic molecules through the thin polymer wall of the nanocapsules. In the present study, we have… CONTINUE READING