Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness.

@article{Tang2008EncapsulationOM,
  title={Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness.},
  author={Wei Tang and Hao Xu and Edwin J Park and Martin A. Philbert and Raoul Kopelman},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={369 2},
  pages={579-83}
}
The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs provide protection for the embedded MB against reduction by diaphorase enzymes. Furthermore, our data shows the matrix-protected MB efficiently induces photodynamic damage to tumor… CONTINUE READING

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