Encapsulation of clomacran phosphate [2-chloro-9[3-(dimethylamino) propyl]acridan phosphate] I. Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredient on weight variation of capsules filled on an automatic capsule-filling machine.

@article{Irwin1970EncapsulationOC,
  title={Encapsulation of clomacran phosphate [2-chloro-9[3-(dimethylamino) propyl]acridan phosphate] I. Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredient on weight variation of capsules filled on an automatic capsule-filling machine.},
  author={George M. Irwin and G. J. Dodson and Louis J. Ravin},
  journal={Journal of pharmaceutical sciences},
  year={1970},
  volume={59 4},
  pages={
          547-50
        }
}
Abstract A correlation has been shown to exist between the flow properties of clomacran phosphate powder blends and capsule fill weight variation when an automatic capsule-filling machine is used.A correlation of 0.96 was obtained for the capsule mixes tested.Weight variation of the finished capsules is also affected by lot-to-lot variability and concentration of clomacran phosphate.Granulation of the active ingredient overcomes most of the problems normally encountered and provides finished… 
Investigation of various factors affecting encapsulation on the In-Cap automatic capsule-filling machine
TLDR
Results of the study showed that pin setting was critical for controlling the fill weight and the weight variation of capsules produced on the In-Cap, and appropriate selection of pin settings and bed height can reduce the weight variability seen, especially with poorly flowing high-dose formulations.
Effects of powder flow properties on capsule filling weight uniformity
TLDR
Powder flow properties of the final blends were significantly correlated to the final capsule weight and weight variability of the filled capsules, and showed that the weight variability decreased with increasing bulk and tapped density, ffc and BFE, while theWeight variability increased with increasing compressibility, cohesion and GDR flow index.
Resistance to Densification, Tensile Strength and Capsule‐filling Performance of some Pharmaceutical Diluents
TLDR
Comparing some indicators of capsule‐filling performance, as measured by tapped density under different conditions, and elucidate possible quantitative relationships between variation of capsule fill‐weight (%CV) and gravitational and inter‐particle forces derived from measurements of particle size, true density, low compression and tensile strength are compared.
Weight and Weight Uniformity of Hard Gelatin Capsules Filled with Microcrystalline Cellulose and Silicified Microcrystalline Cellulose
TLDR
It is suggested that powder flow may not be a critical parameter in ensuring capsule weight uniformity when the encapsulation equipment utilizes a tamping-type filling system.
Methods for determining the technological characteristics of pharmaceutical powders. II. Bulk weight, bulk density, free-flow properties, angle of slope, self-adhesion, and shear strength
The methods for determining the degree of dispersion and wettability of pharmaceutical powders have already been described in [i]. In the present article we discuss the technological characteristics
Relationships between flow properties, compression behaviour and mechanical characteristics of prednisone-microcrystalline cellulose tablets
AbstractThis paper describes the effects on the flow properties, as well as the changes in the compression behaviour, of microcrystalline cellulose (Avicel PH 101) incorporated with prednisone
Flow Studies on Directly Compressible Tablet Vehicles
AbstractA number of methods of estimating ‘flowability’ of some direct compression vehicles have been evaluated as to their usefulness in predicting weight variation on tabletting. There was little
The filling of powders into two-piece hard capsules.
  • B. E. Jones
  • Materials Science
    International journal of pharmaceutics
  • 2001
Prediction of granule packing and flow behavior based on particle size and shape analysis.
TLDR
The use of size and shape distributions in the construction of a model providing both accurate flowability indices and bulk and tap density estimates has been demonstrated for example granular materials in which cohesive forces did not dominate powder behavior.
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References

Evaluation of factors affecting the encapsulation of powders in hard gelatin capsules. I. Semi-automatic capsule machines.
TLDR
A useful model has been developed which relates particulate properties, capsule size, and the operating rate of semi-automatic filling equipment to filled capsule characteristics and is applicable to powder systems other than those from which it was derived.