Encapsulation of clomacran phosphate [2-chloro-9[3-(dimethylamino) propyl]acridan phosphate] I. Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredient on weight variation of capsules filled on an automatic capsule-filling machine.

@article{Irwin1970EncapsulationOC,
  title={Encapsulation of clomacran phosphate [2-chloro-9[3-(dimethylamino) propyl]acridan phosphate] I. Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredient on weight variation of capsules filled on an automatic capsule-filling machine.},
  author={G. M. Irwin and G. J. Dodson and L. J. Ravin},
  journal={Journal of pharmaceutical sciences},
  year={1970},
  volume={59 4},
  pages={
          547-50
        }
}
Abstract A correlation has been shown to exist between the flow properties of clomacran phosphate powder blends and capsule fill weight variation when an automatic capsule-filling machine is used.A correlation of 0.96 was obtained for the capsule mixes tested.Weight variation of the finished capsules is also affected by lot-to-lot variability and concentration of clomacran phosphate.Granulation of the active ingredient overcomes most of the problems normally encountered and provides finished… Expand
Effects of powder flow properties on capsule filling weight uniformity
The filling of powders into two-piece hard capsules.
  • B. E. Jones
  • Materials Science, Medicine
  • International journal of pharmaceutics
  • 2001
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