Encapsulation of cisplatin in a pegylated calcium phosphate nanoparticle (CPNP) for enhanced cytotoxicity to cancerous cells.

@article{Ding2017EncapsulationOC,
  title={Encapsulation of cisplatin in a pegylated calcium phosphate nanoparticle (CPNP) for enhanced cytotoxicity to cancerous cells.},
  author={Yang Ding and Kang Zhai and Pei Pei and Y. X. Lin and Yinchu Ma and Huixia Zhu and Mingfeng Shao and Xianzhu Yang and Wei Tao},
  journal={Journal of colloid and interface science},
  year={2017},
  volume={493},
  pages={181-189}
}
HYPOTHESIS Exchange of the chloride ion (Cl-) ligands of cisplatin with carboxylates is widely used in fabricating cisplatin loaded nanoparticles for improved cancer therapy. However, the dynamic exchange may cause premature cisplatin release and even disintegration of the nanoparticles in Cl--containing medium such as in plasma. Molecules bearing carboxylates are capable of mediating the mineralization process of calcium phosphate; therefore, it is possible to overcome the disadvantage by… CONTINUE READING

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