Encapsulation of bovine serum albumin in poly(lactide-co-glycolide) microspheres by the solid-in-oil-in-water technique.

@article{Castellanos2001EncapsulationOB,
  title={Encapsulation of bovine serum albumin in poly(lactide-co-glycolide) microspheres by the solid-in-oil-in-water technique.},
  author={Ingrid J. Castellanos and Karen G. Carrasquillo and Javier Arturo Hall L{\'o}pez and Mariana Alvarez and Kai Griebenow},
  journal={The Journal of pharmacy and pharmacology},
  year={2001},
  volume={53 2},
  pages={
          167-78
        }
}
Non-aqueous protocols to encapsulate pharmaceutical proteins into biocompatible polymers have gained much attention because they allow for the minimization of procedure-induced protein structural perturbations. The aim of this study was to determine if these advantages could be extended to a semi-aqueous encapsulation procedure, namely the solid-in-oil-in-water (s/o/w) technique. The model protein bovine serum albumin (BSA) was encapsulated into poly(lactide-co-glycolide) (PLG) microspheres by… CONTINUE READING
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