Encapsulation and diffusion of water-soluble dendrimers in a bicontinuous cubic phase

@inproceedings{Jeong2002EncapsulationAD,
  title={Encapsulation and diffusion of water-soluble dendrimers in a bicontinuous cubic phase},
  author={Sang Won Jeong and David O'brien and Greger Oraedd and Goeran Lindblom},
  year={2002}
}
Bicontinuous cubic (QII) phases composed of hydrated lipids are a unique mesoporous organic material. The diameter of the water channels in the range of 5−10 nm could be used as a reservoir for macromolecular therapeutic agents. Here, we describe the synthesis of water-soluble poly(amidoamine) (PAMAM) dendrimer derivatives labeled with fluorine and their diffusion in the water channels of a QII phase. A QII phase with Ia3d symmetry was prepared by hydration of a 9:1 molar mixture of… CONTINUE READING