Encapsulated mesenchymal stromal cells for in vivo transplantation.

  title={Encapsulated mesenchymal stromal cells for in vivo transplantation.},
  author={Jeffrey A Barminko and Jae Hwan Kim and Seiji Otsuka and Andrea Gray and R. P. Schloss and Martin Grumet and Martin L. Yarmush},
  journal={Biotechnology and bioengineering},
  volume={108 11},
Immunomodulatory human mesenchymal stromal cells (hMSC) have been incorporated into therapeutic protocols to treat secondary inflammatory responses post-spinal cord injury (SCI) in animal models. However, limitations with direct hMSC implantation approaches may prevent effective translation for therapeutic development of hMSC infusion into post-SCI treatment protocols. To circumvent these limitations, we investigated the efficacy of alginate microencapsulation in developing an implantable… CONTINUE READING


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