Encapsulated fusion protein confers "sense and respond" activity to chitosan-alginate capsules to manipulate bacterial quorum sensing.

@article{Gupta2013EncapsulatedFP,
  title={Encapsulated fusion protein confers "sense and respond" activity to chitosan-alginate capsules to manipulate bacterial quorum sensing.},
  author={Apoorv Gupta and Jessica L. Terrell and Rohan Fernandes and Matthew Dowling and Gregory F. Payne and Srinivasa R. Raghavan and William E. Bentley},
  journal={Biotechnology and bioengineering},
  year={2013},
  volume={110 2},
  pages={552-62}
}
We demonstrate that "nanofactory"-loaded biopolymer capsules placed in the midst of a bacterial population can direct bacterial communication. Quorum sensing (QS) is a process by which bacteria communicate through small-molecules, such as autoinducer-2 (AI-2), leading to collective behaviors such as virulence and biofilm formation. In our approach, a "nanofactory" construct is created, which comprises an antibody complexed with a fusion protein that produces AI-2. These nanofactories are… CONTINUE READING

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