Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach.

@article{Richter2008EnantiospecificTS,
  title={Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach.},
  author={Jeremy M. Richter and Yoshihiro Ishihara and Takeshi Masuda and Brandon W Whitefield and Tom{\'a}s Llamas and Antti Pohjakallio and Phil S Baran},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 52},
  pages={17938-54}
}
Full details are provided for the total synthesis of several members of the hapalindole family of natural products, including hapalindole Q, 12-epi-hapalindole D, 12-epi-fischerindole U, 12-epi-fischerindole G, 12-epi-fischerindole I, and welwitindolinone A. Use of the recently developed direct indole coupling enabled an efficient, practical, scalable, and protecting-group-free synthesis of each of these natural products. The original biosynthetic proposal is reviewed, and a revised… CONTINUE READING
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