Enantiospecific pharmacokinetics and pharmacodynamics of ketoprofen in sheep.

  title={Enantiospecific pharmacokinetics and pharmacodynamics of ketoprofen in sheep.},
  author={M Fabiana Landoni and W Comas and Nicolas J Mucci and G Anglarilli and D Bidal and Peter D Lees},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={22 6},
Pharmacokinetic and pharmacodynamic parameters were established for the enantiomers of the 2-arylpropionic acid (APA) nonsteroidal anti-inflammatory drug (NSAID), ketoprofen (KTP). Each enantiomer was administered separately (1.5 mg/kg) and in a racemic mixture (3 mg/kg) intravenously (i.v.) to a group of eight sheep in a four-way, four-period cross-over study using a tissue cage model of inflammation. Plasma disposition of each KTP enantiomer was similar following separate administration of… CONTINUE READING