Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2.

@article{Kirchheiner2002EnantiospecificEO,
  title={Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2.},
  author={Julia Kirchheiner and Ingolf Meineke and Georg Tobias Heinrich Freytag and Christian Meisel and Ivar Roots and J{\"u}rgen Brockm{\"o}ller},
  journal={Clinical pharmacology and therapeutics},
  year={2002},
  volume={72 1},
  pages={
          62-75
        }
}
OBJECTIVE According to in vitro data, the polymorphic cytochrome P450 enzyme 2C9 (CYP2C9) may be the major S-ibuprofen hydroxylase. In humans, there are 2 variants of CYP2C9 with a high population frequency. We studied their impact on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2. METHODS Kinetics of an oral dose of 600 mg racemic ibuprofen were studied in 21 healthy volunteers with all combinations of the CYP2C9 variants *2 (arginine144cysteine) and *3… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Similar Papers

Loading similar papers…