Enantioseparation of benzofurys and other novel psychoactive compounds by CE and sulfobutylether β‐cyclodextrin as chiral selector added to the BGE

  title={Enantioseparation of benzofurys and other novel psychoactive compounds by CE and sulfobutylether $\beta$‐cyclodextrin as chiral selector added to the BGE},
  author={Magdalena Taschwer and Manfred G Hofer and Martin G. Schmid},
The illicit drug market of psychoactive substances for human abuse is continuously expanding and developing. Besides already known substance classes like cathinones, amphetamines or synthetic cannabinoids, further derivatives such as benzofurys, thiophenes, and structural analogues of methylphenidate entered the global market recently. As many of these new compounds contain a stereogenic centre it is supposed that their isomers may differ in their pharmacological effects as it is the case with… 

Determination of the chiral status of different novel psychoactive substance classes by capillary electrophoresis and β‐cyclodextrin derivatives

A cheap and easy‐to‐perform chiral capillary zone electrophoresis method for enantioseparation of cathinones presented previously was extended to further chiral compound classes such as amphetamine derivatives, ketamines, 2‐(aminopropyl)benzofurans, and phenidines.

Comparative studies on enantioseparation of New Psychoactive Substances using cyclodextrin-assisted capillary electrophoresis with UV detection

The present study compares the chiral separation power of different previously used non-charged ß-cyclodextrins as well as some of its derivatives with the negatively charged derivatives carboxymethyl-, carboxyethyl- and succinyl-β- cyclodextrin by capillary zone electrophoresis.

Enantioseparation of novel psychoactive chiral amines and their mixture by capillary electrophoresis using cyclodextrins as chiral selectors

The prevalence of new psychoactive substances (NPS) has been increasing during the last decade as well as their constant growth of availability across the whole world. Regardless of the potential

Analysis and characterization of the novel psychoactive drug 4-chloromethcathinone (clephedrone).

Enantiomeric separation of Novel Psychoactive Substances by capillary electrophoresis using (+)-18-crown-6-tetracarboxylic acid as chiral selector.

An easy-to-prepare chiral capillary electrophoresis method for the enantioseparation of NPS which contains a primary amino group by means of (+)-18-crown-6-tetracarboxylic acid as chiral selector is created.

A Simple HPLC–UV Approach for Rapid Enantioseparation of Cathinones, Pyrovalerones and Other Novel Psychoactive Substances on a 2.5-µm Cellulose Tris-(3,5-dimethylphenyl-carbamate) Column

The misuse of so called novel psychoactive substances is still a challenging problem worldwide. A special attribute of a lot of these compounds is a chiral centre enabling two possible enantiomers

Successful use of a novel lux® i-Amylose-1 chiral column for enantioseparation of "legal highs" by HPLC.

A novel HPLC column was tested for the enantioseparation of a set of 112 NPS coming from different chemical groups and collected by internet purchases during the years 2010-2018, and it was found that all separated NPS are traded as racemic compounds.



Chiral separation of cathinone derivatives used as recreational drugs by cyclodextrin‐modified capillary electrophoresis

An easy‐to‐prepare chiral capillary zone electrophoresis method for the enantioseparation of a set of 19 cathinone derivatives was developed and all derivatives except methedrone were resolved in their enantiomers within 20 min.

Chiral separation of cathinone derivatives used as recreational drugs by HPLC-UV using a CHIRALPAK® AS-H column as stationary phase.

A reliable and easy-to-perform high-performance liquid chromatography ultraviolet method for the chiral separation of a set of 24 cathinone derivatives and a correlation between the substituents of the nitrogen atom and the separation results are shown.

Enantiomeric separation of 13 new amphetamine-like designer drugs by capillary electrophoresis, using modified-B-cyclodextrins.

An easy-to-prepare chiral CE method for the enantiomeric separation of 13 new amphetamine-like designer drugs, using CDs as chiral selectors, was developed. Sulfated-β-CD was found to be the best

Chiral determination of amphetamine and related compounds using chloroformates for derivatization and high-performance liquid chromatography.

The enantiomeric determination of amphetamine and various amphetamine-type compounds by liquid chromatography after chiral derivatization with 9-fluorenylmethyl chloroformate-L-proline (FMOC- L-Pro) is reported and possible conditions for the determination of each amphetamine are indicated.

Enantiomeric separation of dihydroxyphenyl‐alanine (DOPA), methyldihydroxyphenylalanine (MDOPA) and hydrazinomethyldihydroxyphenyl‐alanine (CDOPA) by using capillary electrophoresis with sulfobutyl ether‐β‐cyclodextrin as a chiral selector

Capillary electrophoresis (CE) was successfully applied to the enantiomer resolution of racemic structurally related compounds, namely DOPA, methyldihydroxyphenylalanine (MDOPA) and hydrazinomethyldihytochemical isomer (CDOPA), to obtain inversion of migration order.

Methcathinone (“cat”): An enantiomeric potency comparison

Simultaneous chiral separation of methylamphetamine and common precursors using gas chromatography/mass spectrometry.

A temperature-programmed method was developed and optimized and the results compared with those obtained using a previously published isothermal GC method applied to GC/MS analysis, surpassing the UNODC's acceptance criteria of 2% for validation of qualitative precision.