Enantioselective total synthesis of (+)-cassiol.

  title={Enantioselective total synthesis of (+)-cassiol.},
  author={Krastina V Petrova and Justin T Mohr and Brian M Stoltz},
  journal={Organic letters},
  volume={11 2},
An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd(2)(pmdba)(3) and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early stage. The overall synthetic strategy involves a convergent late-stage coupling of two fragments. The… CONTINUE READING