Enantioselective total synthesis and absolute configuration of apiosporic acid.

@article{Grtner2012EnantioselectiveTS,
  title={Enantioselective total synthesis and absolute configuration of apiosporic acid.},
  author={Martin G{\"a}rtner and D Kossler and Daniel Pfl{\"a}sterer and G{\"u}nter Helmchen},
  journal={The Journal of organic chemistry},
  year={2012},
  volume={77 9},
  pages={4491-5}
}
The first total synthesis of the polyketide apiosporic acid is presented. Key steps are a Julia-Kocienski olefination, a Suzuki-Miyaura cross-coupling, and an intramolecular Diels-Alder reaction. The absolute configuration of the natural product was determined.