Enantioselective synthesis of tertiary α-hydroxy phosphonates catalyzed by carbohydrate/cinchona alkaloid thiourea organocatalysts.

@article{Kong2012EnantioselectiveSO,
  title={Enantioselective synthesis of tertiary α-hydroxy phosphonates catalyzed by carbohydrate/cinchona alkaloid thiourea organocatalysts.},
  author={Shasha Kong and Weidong Fan and Guiping Wu and Zhiwei Miao},
  journal={Angewandte Chemie},
  year={2012},
  volume={51 35},
  pages={8864-7}
}
Functionalization of Ca H bonds in phosphonic acid compounds have attracted extensive attention because of their use in pharmaceutical applications and excellent inhibitory bioactivities towards several important groups of enzymes, including rennin, HIV protease, and various classes of protein tyrosine kinases and phosphatases. It has been established that the biological activity of phosphonic acids is largely determined by the absolute configuration of the stereogenic a-carbon atom. The… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-7 of 7 references

Recent reviews on enantioselective reactions catalyzed by hydrogen-bond donors

  • J. D. McGilvra, V. B. Gondi, V. H. Rawal
  • Dalko), Wiley-VCH, Weinheim,
  • 2007
1 Excerpt

Recent reviews on enantioselective reactions catalyzed by hydrogen - bond donors : a )

  • V. B. Gondi, K. Hagihara, V. H. Rawal
  • 2006

For examples of hydrogen-bond-catalyzed asymmetric reactions of imines and carbonyl electrophiles

  • M. S. Sigman, P. Vachal, E. N. Jacobsen, Angew. Chem
  • Angew. Chem. Int. Ed
  • 2000
1 Excerpt

For a review on the synthetic utility of cyanohydrins see : R

  • L. Raimondi, L. Lay, L. Poletti
  • . J . H . Gregory , Chem . Rev .
  • 1999

For selected examples on chemical methods : a ) D . F

  • P. Kafarski
  • . Wiemer , Tetrahedron
  • 1998

The Role of Phosphonates in Living Systems, CRC

  • R. L. Hilderbrand, T. O. Henderson
  • Boca Raton,
  • 1983
1 Excerpt

For selected examples of the bifunctional Cinchona alkaloid derivatives , see : a ) B . Vakulya , S . Varga , A . Cs  mpai , T . So  s

  • K. Soga, N. Momiyama

Similar Papers

Loading similar papers…