Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation.

Abstract

An organocatalytic construction of optically enriched substituted pyran derivatives via amine-catalyzed Michael addition and subsequent enolization/cyclisation has been described starting from electronically poor alkenes. Functionalized pyrans were obtained in high enantioselectivities (up to 96%) and good yields (up to 90%) having three contiguous chiral… (More)
DOI: 10.1039/c2cc31445b

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@article{Das2012EnantioselectiveSO, title={Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation.}, author={Utpal Kumar Das and Chan-Hui Huang and Wenwei Lin}, journal={Chemical communications}, year={2012}, volume={48 45}, pages={5590-2} }