Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.

Abstract

An enantioselective synthesis of the (1'S,2'R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC (3). Pharmacology, in vivo and in vitro, indicate (3) to be one of the most potent traditional cannabinoids known. 

Topics

Cite this paper

@article{Liddle1998EnantioselectiveSA, title={Enantioselective synthesis and pharmacology of 11-hydroxy-(1'S,2'R)-dimethylheptyl-delta 8-THC.}, author={J Alexander Liddle and J. W. Huffman and J. L. Wiley and B. R. Martin}, journal={Bioorganic & medicinal chemistry letters}, year={1998}, volume={8 16}, pages={2223-6} }