Enantioselective syntheses of the proposed structures of kopeolin and kopeolone.

@article{Miquet2013EnantioselectiveSO,
  title={Enantioselective syntheses of the proposed structures of kopeolin and kopeolone.},
  author={St{\'e}phanie Miquet and N. Vanthuyne and Paul Br{\'e}mond and G. Audran},
  journal={Chemistry},
  year={2013},
  volume={19 32},
  pages={
          10632-42
        }
}
The first total syntheses of the proposed structures of kopeolin (1) and kopeolone (3) have been achieved from a common enantiopure chiral building block obtained by a chemoenzymatic enantioconvergent methodology. The syntheses feature two key steps: a one-pot reduction/diastereoselective protonation followed by a highly diastereoselective addition of an organocerate. The synthetic structures were fully characterized and all stereocenters were confirmed. The results show that the two previously… Expand
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