Enantioselective syntheses of the proposed structures of cytotoxic macrolides iriomoteolide-1a and -1b.

Abstract

Enantioselective total syntheses of the proposed structures of macrolide cytotoxic agents iriomoteolide-1a and -1b have been accomplished. The synthesis was carried out in a convergent and stereoselective manner. However, the present work suggests that the reported structures have been assigned incorrectly. The synthesis features Julia-Kocienski olefination… (More)
DOI: 10.1021/ol101105v

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