Enantioselective steady-state kinetics of unbound disopyramide and its dealkylated metabolite in man


Disopyramide is provided as a racemic mixture of R and S enantiomers, which have different pharmacodynamic and pharmacokinetic characteristics. Five volunteers were given racemic disopyramide 100 mg and 200 mg t.d.s. in a cross-over design. Plasma and urine concentrations of disopyramide and its active metabolite monodesisopropyl-disopyramide (MND) were… (More)
DOI: 10.1007/BF00626374


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