Enantioselective protein binding of semotiadil and levosemotiadil determined by high-performance frontal analysis.

@article{Rosas1997EnantioselectivePB,
  title={Enantioselective protein binding of semotiadil and levosemotiadil determined by high-performance frontal analysis.},
  author={M E Rodriguez Rosas and Akimasa Shibukawa and Kaoru Ueda and Terumichi Nakagawa},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={1997},
  volume={15 9-10},
  pages={1595-601}
}
An on-line frontal analysis HPLC system was developed for the determination of the unbound concentrations of semotiadil, a new calcium antagonist with non-dihydropyridine structure, and its antipode (Levosemotiadil), and was applied to the enantioselective investigation of their plasma protein binding properties. This system consists of a high-performance frontal analysis (HPFA) column, an extraction column, and an analytical column, which are connected via two switching valves. After the… CONTINUE READING