Enantioselective pharmacokinetics of primaquine in healthy human volunteers.

@article{Tekwani2015EnantioselectivePO,
  title={Enantioselective pharmacokinetics of primaquine in healthy human volunteers.},
  author={Babu L. Tekwani and Bharathi Avula and Rajnish Sahu and Narayan Das Chaurasiya and Sirajul Islam Khan and Surendra Kumar Jain and Pius S Fasinu and H. M. Bandara Herath and Donald Stanford and N. P. Dhammika Nanayakkara and James D. Mcchesney and Travis W Yates and Mahmoud A ElSohly and Ikhlas A Khan and Larry A Walker},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2015},
  volume={43 4},
  pages={
          571-7
        }
}
Primaquine (PQ), a racemic drug, is the only treatment available for radical cure of relapsing Plasmodium vivax malaria and blocking transmission of P. falciparum malaria. Recent studies have shown differential pharmacologic and toxicologic profiles of individual PQ enantiomers in rodent, dog, and primate animal models. This study was conducted in six healthy adult human volunteers to determine the plasma pharmacokinetic profile of enantiomers of PQ and carboxyprimaquine (cPQ), the major plasma… CONTINUE READING
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Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine

  • D Saunders, P Teja-isavadharm, +9 authors LA Walker
  • 2014
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