Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols.


The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition-hemiaminalization sequence using the Jørgensen-Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion.

DOI: 10.1039/c2cc35644a

Cite this paper

@article{Wan2012EnantioselectiveOD, title={Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols.}, author={Jie-Ping Wan and Charles C J Loh and Fangfang Pan and Dieter Enders}, journal={Chemical communications}, year={2012}, volume={48 80}, pages={10049-51} }