Enantioselective organocatalytic approach to alpha-methylene-delta-lactones and delta-lactams.

@article{Albrecht2008EnantioselectiveOA,
  title={Enantioselective organocatalytic approach to alpha-methylene-delta-lactones and delta-lactams.},
  author={Łukasz Albrecht and Bo Richter and Henryk Krawczyk and Karl Anker J\orgensen},
  journal={The Journal of organic chemistry},
  year={2008},
  volume={73 21},
  pages={8337-43}
}
We present the first enantioselective organocatalytic approach for the synthesis of alpha-methylene-delta-lactones and delta-lactams. Our methodology utilizes the Michael addition of unmodified aldehydes to ethyl 2-(diethoxyphosphoryl)acrylate as the key step affording highly enantiomerically enriched adducts, which can be transformed into the target… CONTINUE READING