Enantioselective nitro-Michael reactions catalyzed by short peptides on water.

Abstract

Simple unmodified N-proline-based di- and tripeptides in combination with sodium hydroxide additive catalyze the asymmetric Michael reaction of ketones with nitroolefins to furnish the corresponding gamma-nitroketones with up to 99% yield, 99:1 dr and 70% ee at room temperature and on water without any organic cosolvent.

DOI: 10.1039/b910249c

Cite this paper

@article{Freund2009EnantioselectiveNR, title={Enantioselective nitro-Michael reactions catalyzed by short peptides on water.}, author={Matthias Freund and Sebastian Schenker and Svetlana B. Tsogoeva}, journal={Organic & biomolecular chemistry}, year={2009}, volume={7 20}, pages={4279-84} }