Enantioselective hydrogenation of alpha-aryloxy alpha,beta-unsaturated acids. Asymmetric synthesis of alpha-aryloxycarboxylic acids.

Abstract

[reaction: see text] A facile preparation of chiral alpha-aryloxy carboxylic acids via asymmetric hydrogenation of the corresponding unsaturated acids has been discovered. A number of catalysts have been identified that give high product enantioselectivity, and the scope of the reaction has been examined with respect to substitution on the aromatic ring and… (More)

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Cite this paper

@article{Maligres2004EnantioselectiveHO, title={Enantioselective hydrogenation of alpha-aryloxy alpha,beta-unsaturated acids. Asymmetric synthesis of alpha-aryloxycarboxylic acids.}, author={Peter Maligres and Shane W. Krska and Guy R Humphrey}, journal={Organic letters}, year={2004}, volume={6 18}, pages={3147-50} }