Enantioselective disposition of lansoprazole and rabeprazole in human plasma.

  title={Enantioselective disposition of lansoprazole and rabeprazole in human plasma.},
  author={Masatomo Miura},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  volume={126 6},
  • Masatomo Miura
  • Published 2006 in
    Yakugaku zasshi : Journal of the Pharmaceutical…
Lansoprazole is extensively metabolized by CYP2C19 and CYP3A4 in the liver, whereas rabeprazole is primarily converted non-enzymatically to rabeprazole-thioether, with only some being oxidized by CYP2C19 and CYP3A4. Lansoprazole and rabeprazole possess asymmetric sulfur in their chemical structure and have typically been used clinically as a racemic mixture. This article reviews the pharmacokinetic differences between enantiomers of lansoprazole and rabeprazole in relation to the CYP2C19… CONTINUE READING


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