Enantioselective copper(I/II)-catalyzed conjugate addition of nitro esters to β,γ-unsaturated α-ketoesters.

@article{Zhang2014EnantioselectiveCC,
  title={Enantioselective copper(I/II)-catalyzed conjugate addition of nitro esters to β,γ-unsaturated α-ketoesters.},
  author={Sheng Zhang and Kun Xu and Fengfeng Guo and Yanbin Hu and Zhenggen Zha and Zhiyong Wang},
  journal={Chemistry},
  year={2014},
  volume={20 4},
  pages={979-82}
}
A highly enantioselective Michael addition of nitroacetates to β,γ-unsaturated α-ketoesters was developed by using chiral copper catalysts. The Michael addition products can be obtained in high yields with up to 99 % ee. With these densely functionalized products, the chiral cyclic nitrones, which are important synthetic intermediates, can be obtained in… CONTINUE READING